Step	Pathway	KO	FRH46_2	FRH46_3	FRH46_4	FRH46_5	FRH46_6	FRH47_2	FRH47_3	FRH47_4	FRH47_5	FRH47_6	FRH48_2	FRH48_3	FRH48_4	FRH48_5	FRH48_6	FRH49_3	FRH49_4	FRH49_5	FRH49_6	FRH50_3	FRH50_4	FRH50_5	FRH50_6	FRH51_2	FRH51_3	FRH51_4	FRH51_5	FRH51_6	FRH52_2	FRH52_3	FRH52_4	FRH52_5	FRH52_6	FRHG53_2	FRH53_3	FRH53_4	FRH53_5	FRH53_6	FRH54_2	FRH54_3	FRH54_4	FRH54_5	FRH54_6	FRH55_2	FRH55_3	FRH55_4	FRH55_5	FRH55_6	FRH56_2	FRH56_3	FRH56_4	FRH56_5	FRH56_6	FRH57_3	FRH57_4	FRH57_5	FRH57_6
Acetyl-CoA to Pyruvate	Reductive citrate cycle	K00169	4	1	4	1	4	2	7	12	25	18	8	3	3	2	13	1	1	13	18	1	4	28	25	1	0	2	2	3	0	9	17	18	26	0	6	8	25	45	1	0	8	1	2	0	1	1	5	17	0	0	9	0	3	14	8	26	39
Acetyl-Co-A to Pyruvate	Reductive citrate cycle	K03737	27	42	60	18	62	6	25	42	54	79	15	6	5	18	32	33	41	64	60	14	15	72	98	12	11	8	11	12	0	17	25	25	32	3	17	16	31	44	8	5	12	12	18	4	5	8	26	38	6	4	14	4	14	17	10	25	51
Pyruvate to Phosphoenolpyruvate	Reductive citrate cycle	K01006	53	54	89	34	107	12	132	258	300	287	30	12	16	65	198	80	76	149	138	66	122	321	311	17	20	17	29	40	0	47	61	106	142	2	72	110	258	302	9	6	30	14	24	9	8	13	47	167	12	3	47	5	28	118	82	211	305
Pyruvate to Phosphoenol-pyruvate	Reductive citrate cycle	K01007	41	10	25	23	32	16	69	124	169	106	23	17	15	28	87	20	16	47	44	13	31	130	99	8	8	5	9	13	0	30	40	47	86	6	42	53	132	155	26	0	73	11	12	1	1	7	19	80	16	1	34	1	17	67	39	120	163
Phosphoenol-pyruvate to Oxaloacetate	Reductive citrate cycle	K01958	16	23	30	11	31	5	25	46	57	50	6	16	13	11	39	19	17	23	18	14	36	72	41	7	4	6	10	11	0	11	19	17	17	2	15	28	45	50	10	1	30	7	9	2	2	6	12	33	7	1	15	0	9	25	19	36	57
Phosphoenol pyruvate to Oxaloacteate	Reductive citrate cycle	K01595	61	6	26	36	38	24	87	146	187	119	23	23	23	45	114	38	29	60	53	34	73	178	128	15	14	14	14	20	1	32	35	46	75	7	50	69	141	153	31	2	82	14	13	4	6	8	23	110	29	4	40	3	25	69	50	133	182
Oxaloacetate to S-Malate	Reductive citrate cycle	K00024	86	25	58	56	88	37	194	356	426	333	46	32	34	97	269	84	65	151	143	76	154	396	341	23	29	29	43	58	1	65	77	131	189	11	113	163	357	410	42	4	115	16	23	10	9	18	49	224	35	7	78	4	41	172	118	311	438
S-Malate to Fumarate (bidirectional)	Reductive citrate cycle	K01676	39	9	20	28	36	20	68	124	160	105	22	18	20	35	84	37	29	54	52	32	51	154	132	12	10	12	19	21	0	24	27	39	60	9	44	62	115	108	31	0	88	12	17	4	3	5	21	84	15	1	40	0	19	60	42	101	128
Fumarate to Succinate (bidirectional)	Reductive citrate cycle	K00239	90	28	61	58	92	37	196	360	431	334	46	39	35	98	271	83	65	154	145	76	156	402	343	25	31	29	43	57	1	68	83	134	196	11	113	164	361	417	44	4	118	17	25	10	9	19	49	226	37	7	79	6	46	176	119	315	447
Fumarate to Succinate (bidirectional)	Reductive citrate cycle	K00244	6	3	4	8	8	7	13	16	24	10	4	1	1	5	10	7	6	7	5	9	11	18	15	4	3	2	2	5	0	4	4	0	6	1	12	13	15	18	7	0	20	4	4	1	1	3	6	5	4	1	9	0	5	10	6	8	11
Succinate to Succinyl-CoA	Reductive citrate cycle	K01902	90	35	70	59	102	38	198	363	434	341	48	40	37	101	274	88	74	157	148	81	163	409	348	27	36	32	47	61	1	72	89	139	199	11	111	165	363	417	46	6	119	19	27	12	11	21	55	230	38	8	83	4	45	176	120	314	446
Succinyl-CoA to 2-Oxoglutarate	Reductive citrate cycle	K00174	34	36	54	14	59	6	50	119	141	147	20	10	8	30	86	33	35	91	88	17	28	153	174	17	5	7	12	16	0	29	46	51	91	3	34	42	115	182	8	2	31	9	17	4	4	7	27	80	8	2	26	4	23	55	31	109	187
2-Oxoglutarate to Isocitrate	Reductive citrate cycle	K00031	93	38	75	60	107	39	201	366	440	345	46	39	36	101	275	90	81	160	148	80	164	404	346	28	37	33	48	62	1	72	91	143	196	12	112	164	356	402	47	7	122	21	31	13	12	21	58	232	38	8	84	4	46	173	118	310	442
Isocitrate to cis-Aconitate	Reductive citrate cycle	K01681	97	57	99	61	124	37	197	361	433	343	48	40	38	99	274	98	85	170	153	80	161	406	351	28	35	32	47	63	1	75	91	138	197	11	110	164	355	411	46	7	120	24	31	12	11	21	61	235	37	8	84	7	48	173	117	306	440
cis-Aconitate to Citrate	Reductive citrate cycle	K01681	97	57	99	61	124	37	197	361	433	343	48	40	38	99	274	98	85	170	153	80	161	406	351	28	35	32	47	63	1	75	91	138	197	11	110	164	355	411	46	7	120	24	31	12	11	21	61	235	37	8	84	7	48	173	117	306	440
CO2 to CO	Wood-Ljungdahl pathway	K00198	1	3	6	2	4	0	1	1	6	10	7	2	1	0	2	2	4	14	18	0	2	11	20	3	0	0	1	1	0	1	7	2	0	0	1	3	4	4	0	0	3	0	1	0	0	1	2	6	0	0	1	0	0	2	0	4	6
CO to Acetyl-CoA	Wood-Ljungdahl pathway	K14138	1	1	4	1	2	0	0	0	3	8	6	1	0	0	0	1	1	10	15	0	1	6	14	2	0	0	1	1	0	1	4	2	0	0	0	1	4	1	0	0	2	0	1	0	0	1	1	2	0	0	0	0	0	1	0	1	2
CO to Tetrahydrofolate (THF)	Wood-Ljungdahl pathway	K14138	1	1	4	1	2	0	0	0	3	8	6	1	0	0	0	1	1	10	15	0	1	6	14	2	0	0	1	1	0	1	4	2	0	0	0	1	4	1	0	0	2	0	1	0	0	1	1	2	0	0	0	0	0	1	0	1	2
Tetrahydofolate to 10-Formyl-THF	Wood-Ljungdahl pathway	K01938	31	43	67	21	74	10	70	106	149	123	20	16	13	28	92	43	43	72	63	39	73	162	139	12	13	14	21	28	0	23	34	43	47	2	35	62	111	117	14	3	45	11	17	6	7	11	31	89	9	1	29	3	18	58	44	96	123
10-Formyl-THF to 5,10-Methenylene-THF	Wood-Ljungdahl pathway	K01491	104	61	106	65	131	39	204	371	446	356	50	40	38	103	282	102	92	181	162	82	164	418	365	31	37	33	48	64	1	78	97	147	206	12	115	167	368	424	48	8	124	26	36	13	13	23	65	241	38	8	87	7	52	179	120	316	451
5,10-Methenyl-THF to 5,10-Methylene-THF	Wood-Ljungdahl pathway	K01491	104	61	106	65	131	39	204	371	446	356	50	40	38	103	282	102	92	181	162	82	164	418	365	31	37	33	48	64	1	78	97	147	206	12	115	167	368	424	48	8	124	26	36	13	13	23	65	241	38	8	87	7	52	179	120	316	451
5,10-Methylene-THF to 5-Methyl-THF	Wood-Ljungdahl pathway	K00297	91	52	90	61	117	36	181	328	401	309	47	36	34	95	258	90	81	159	141	79	160	394	328	24	36	29	45	61	1	69	86	137	179	8	101	145	329	357	37	8	94	23	33	13	11	21	56	220	35	8	76	7	41	158	111	283	404
5-Methyl-THF to THF	Wood-Ljungdahl pathway	K15023	1	2	5	2	3	0	0	0	3	9	6	1	0	0	0	1	1	10	15	0	1	6	14	2	0	0	1	1	0	1	4	2	0	0	0	1	2	1	0	0	2	0	1	0	0	1	1	2	0	0	1	0	0	1	0	2	3
Acetate to Acetyl phosphate (bidirectional)	Phosphate acetyltransferase-acetate kinase pathway	K00925	65	48	78	42	87	20	106	187	227	210	30	20	18	50	128	58	60	115	102	42	74	225	218	20	14	16	20	26	0	48	65	84	114	10	58	73	170	208	40	5	92	21	30	5	7	13	40	129	26	3	57	6	37	84	53	139	227
Acetyl phosphate to Acetyl-CoA (bidirectional	Phosphate acetyltransferase-acetate kinase pathway	K00625	19	22	35	13	36	4	17	28	36	51	6	8	10	16	25	19	27	40	41	12	22	64	70	12	8	10	13	13	0	12	12	18	16	4	10	19	26	21	14	4	29	11	17	4	6	6	23	27	5	1	17	3	16	14	8	12	26
Acetyl-CoA to Pyruvate	Dicarboxylate-hydroxybutyrate cycle	K00169	4	1	4	1	4	2	7	12	25	18	8	3	3	2	13	1	1	13	18	1	4	28	25	1	0	2	2	3	0	9	17	18	26	0	6	8	25	45	1	0	8	1	2	0	1	1	5	17	0	0	9	0	3	14	8	26	39
Pyruvate to Phosphoenol-pyruvate	Dicarboxylate-hydroxybutyrate cycle	K01007	41	10	25	23	32	16	69	124	169	106	23	17	15	28	87	20	16	47	44	13	31	130	99	8	8	5	9	13	0	30	40	47	86	6	42	53	132	155	26	0	73	11	12	1	1	7	19	80	16	1	34	1	17	67	39	120	163
Phosphoenol-pyruvate to Oxaloacetate	Dicarboxylate-hydroxybutyrate cycle	K01958	16	23	30	11	31	5	25	46	57	50	6	16	13	11	39	19	17	23	18	14	36	72	41	7	4	6	10	11	0	11	19	17	17	2	15	28	45	50	10	1	30	7	9	2	2	6	12	33	7	1	15	0	9	25	19	36	57
Oxaloacetate to S-Malate	Dicarboxylate-hydroxybutyrate cycle	K00024	86	25	58	56	88	37	194	356	426	333	46	32	34	97	269	84	65	151	143	76	154	396	341	23	29	29	43	58	1	65	77	131	189	11	113	163	357	410	42	4	115	16	23	10	9	18	49	224	35	7	78	4	41	172	118	311	438
S-Malate to Fumarate (bidirectional)	Dicarboxylate-hydroxybutyrate cycle	K01676	39	9	20	28	36	20	68	124	160	105	22	18	20	35	84	37	29	54	52	32	51	154	132	12	10	12	19	21	0	24	27	39	60	9	44	62	115	108	31	0	88	12	17	4	3	5	21	84	15	1	40	0	19	60	42	101	128
Fumarate to Succinate (bidirectional)	Dicarboxylate-hydroxybutyrate cycle	K00239	90	28	61	58	92	37	196	360	431	334	46	39	35	98	271	83	65	154	145	76	156	402	343	25	31	29	43	57	1	68	83	134	196	11	113	164	361	417	44	4	118	17	25	10	9	19	49	226	37	7	79	6	46	176	119	315	447
Fumarate to Succinate (bidirectional)	Dicarboxylate-hydroxybutyrate cycle	K00244	6	3	4	8	8	7	13	16	24	10	4	1	1	5	10	7	6	7	5	9	11	18	15	4	3	2	2	5	0	4	4	0	6	1	12	13	15	18	7	0	20	4	4	1	1	3	6	5	4	1	9	0	5	10	6	8	11
Succinate to Succinyl-CoA	Dicarboxylate-hydroxybutyrate cycle	K01902	90	35	70	59	102	38	198	363	434	341	48	40	37	101	274	88	74	157	148	81	163	409	348	27	36	32	47	61	1	72	89	139	199	11	111	165	363	417	46	6	119	19	27	12	11	21	55	230	38	8	83	4	45	176	120	314	446
4-Hydroxybutanoate to 4-Hydroxybuatanoyl-CoA	Dicarboxylate-hydroxybutyrate cycle	K14466	0	1	2	1	1	0	0	0	2	1	1	0	0	0	0	0	0	3	6	0	0	2	4	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
4-Hydroxybutanoyl-CoA to Crotnoyl-CoA	Dicarboxylate-hydroxybutyrate cycle	K14534	0	0	1	1	1	0	0	2	4	1	5	0	0	0	0	0	0	5	10	0	0	5	10	1	0	1	2	2	0	0	0	2	1	0	1	1	3	2	0	0	1	0	1	0	0	0	0	1	0	0	0	0	0	0	0	3	3
Crotonyl-CoA to (S)-3-Hydroxybutanoyl-CoA	Dicarboxylate-hydroxybutyrate cycle	K15016	0	0	2	1	1	0	0	1	3	3	3	1	2	0	0	0	0	3	6	1	0	3	5	0	0	0	0	0	0	0	2	0	0	0	1	0	1	2	0	0	1	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0
(S)-3-Hydroxybutanoyl-CoA to Acetoacetyl-CoA	Dicarboxylate-hydroxybutyrate cycle	K15016	0	0	2	1	1	0	0	1	3	3	3	1	2	0	0	0	0	3	6	1	0	3	5	0	0	0	0	0	0	0	2	0	0	0	1	0	1	2	0	0	1	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0
Acetoacetyl-CoA to Acetyl-CoA	Dicarboxylate-hydroxybutyrate cycle	K00626	90	44	80	58	102	36	181	337	414	312	43	36	34	89	262	88	71	143	124	74	153	373	302	23	28	27	40	55	1	70	88	134	189	11	105	153	336	388	42	6	119	23	31	11	9	18	51	222	34	7	80	7	46	168	112	295	419
Acetyl-CoA to Malonyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K02160	86	27	63	55	92	36	189	335	399	318	43	29	36	97	258	83	72	149	131	74	152	354	315	28	31	29	44	58	1	65	73	123	175	10	102	150	331	364	43	4	112	22	26	10	9	17	50	218	32	7	72	4	42	160	110	284	406
Malonyl-CoA to Malonate semialdehyde	Hydroxypropionate-hydroxybutyrate cycle	K14468	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Malonate semialdehyde to 3-Hydroxypropanoate	Hydroxypropionate-hydroxybutyrate cycle	K14468	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0
3-Hydroxypropanoate to 3-Hydroxypropionyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K14469	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0
3-Hydroxpropionyl-CoA to Acryloyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K14469	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Acruloyl-CoA to Propionyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K14469	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Propionyl-CoA to (S)-Methylmalonyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K15052	0	0	0	0	0	0	0	1	2	2	0	0	0	1	2	0	0	0	0	0	0	2	2	0	0	0	1	0	0	2	2	0	1	0	0	0	0	3	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1
(S)-Methylmalonyyl-CoA to R-Methylmalonyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K05606	54	38	64	37	82	22	128	234	281	216	29	20	23	68	192	69	60	109	102	66	131	288	240	21	23	22	35	46	1	39	46	83	115	4	72	109	237	240	13	5	42	8	15	8	7	14	33	147	21	6	40	3	21	115	82	190	260
R-Methylmalonyl-CoA to Succinyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K01847	46	19	38	35	61	21	100	171	210	154	18	14	17	51	140	56	48	75	72	58	115	215	170	15	22	23	34	43	1	26	27	56	61	5	57	91	168	142	13	3	40	4	11	9	7	13	28	114	20	4	28	2	15	82	69	142	178
4-Hydroxybutanoate to 4-Hydroxybuatanoyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K14466	0	1	2	1	1	0	0	0	2	1	1	0	0	0	0	0	0	3	6	0	0	2	4	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
4-Hydroxybutanoyl-CoA to Crotnoyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K14534	0	0	1	1	1	0	0	2	4	1	5	0	0	0	0	0	0	5	10	0	0	5	10	1	0	1	2	2	0	0	0	2	1	0	1	1	3	2	0	0	1	0	1	0	0	0	0	1	0	0	0	0	0	0	0	3	3
Crotonyl-CoA to (S)-3-Hydroxybutanoyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K15016	0	0	2	1	1	0	0	1	3	3	3	1	2	0	0	0	0	3	6	1	0	3	5	0	0	0	0	0	0	0	2	0	0	0	1	0	1	2	0	0	1	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0
(S)-3-Hydroxybutanoyl-CoA to Acetoacetyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K15016	0	0	2	1	1	0	0	1	3	3	3	1	2	0	0	0	0	3	6	1	0	3	5	0	0	0	0	0	0	0	2	0	0	0	1	0	1	2	0	0	1	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0
Acetoacetyl-CoA to Acetyl-CoA	Hydroxypropionate-hydroxybutyrate cycle	K00626	90	44	80	58	102	36	181	337	414	312	43	36	34	89	262	88	71	143	124	74	153	373	302	23	28	27	40	55	1	70	88	134	189	11	105	153	336	388	42	6	119	23	31	11	9	18	51	222	34	7	80	7	46	168	112	295	419
Acetyl-CoA to Malonyl-CoA	3-Hydroxypropionate bi-cycle	K08691	9	8	16	8	29	5	38	63	78	59	5	0	5	17	54	19	21	30	21	21	42	69	60	3	5	6	13	14	0	7	10	20	20	0	15	29	65	52	1	0	6	0	2	4	3	3	10	40	3	0	11	0	2	32	28	56	68
Malonyl-CoA to Malonate semialdehyde	3-Hydroxypropionate bi-cycle	K14468	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0
Malonate semialdehyde to 3-Hydroxypropanoate	3-Hydroxypropionate bi-cycle	K14468	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0
3-Hydroxypropanoate to 3-Hydroxypropionyl-CoA	3-Hydroxypropionate bi-cycle	K14469	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0
3-Hydroxpropionyl-CoA to Acryloyl-CoA	3-Hydroxypropionate bi-cycle	K14469	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Acruloyl-CoA to Propionyl-CoA	3-Hydroxypropionate bi-cycle	K14469	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	1	0	1	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	1	0
Propionyl-CoA to (S)-Methylmalonyl-CoA	3-Hydroxypropionate bi-cycle	K15052	0	0	0	0	0	0	0	1	2	2	0	0	0	1	2	0	0	0	0	0	0	2	2	0	0	0	1	0	0	2	2	0	1	0	0	0	0	3	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1
(S)-Methylmalonyyl-CoA to R-Methylmalonyl-CoA	3-Hydroxypropionate bi-cycle	K05606	54	38	64	37	82	22	128	234	281	216	29	20	23	68	192	69	60	109	102	66	131	288	240	21	23	22	35	46	1	39	46	83	115	4	72	109	237	240	13	5	42	8	15	8	7	14	33	147	21	6	40	3	21	115	82	190	260
R-Methylmalonyl-CoA to Succinyl-CoA	3-Hydroxypropionate bi-cycle	K01847	46	19	38	35	61	21	100	171	210	154	18	14	17	51	140	56	48	75	72	58	115	215	170	15	22	23	34	43	1	26	27	56	61	5	57	91	168	142	13	3	40	4	11	9	7	13	28	114	20	4	28	2	15	82	69	142	178
Fumarate to Succinate (bidirectional)	3-Hydroxypropionate bi-cycle	K00239	90	28	61	58	92	37	196	360	431	334	46	39	35	98	271	83	65	154	145	76	156	402	343	25	31	29	43	57	1	68	83	134	196	11	113	164	361	417	44	4	118	17	25	10	9	19	49	226	37	7	79	6	46	176	119	315	447
Fumarate to Succinate (bidirectional)	3-Hydroxypropionate bi-cycle	K00244	6	3	4	8	8	7	13	16	24	10	4	1	1	5	10	7	6	7	5	9	11	18	15	4	3	2	2	5	0	4	4	0	6	1	12	13	15	18	7	0	20	4	4	1	1	3	6	5	4	1	9	0	5	10	6	8	11
Fumarate to S-Malate (bidirectional)	3-Hydroxypropionate bi-cycle	K01676	39	9	20	28	36	20	68	124	160	105	22	18	20	35	84	37	29	54	52	32	51	154	132	12	10	12	19	21	0	24	27	39	60	9	44	62	115	108	31	0	88	12	17	4	3	5	21	84	15	1	40	0	19	60	42	101	128
L-Malonyl-CoA to Acetyl-CoA	3-Hydroxypropionate bi-cycle	K08691	9	8	16	8	29	5	38	63	78	59	5	0	5	17	54	19	21	30	21	21	42	69	60	3	5	6	13	14	0	7	10	20	20	0	15	29	65	52	1	0	6	0	2	4	3	3	10	40	3	0	11	0	2	32	28	56	68
Propionyl-CoA to beta-Methylmalyl-CoA	3-Hydroxypropionate bi-cycle	K08691	9	8	16	8	29	5	38	63	78	59	5	0	5	17	54	19	21	30	21	21	42	69	60	3	5	6	13	14	0	7	10	20	20	0	15	29	65	52	1	0	6	0	2	4	3	3	10	40	3	0	11	0	2	32	28	56	68
beta-Methylmalyl-CoA to 2-Methylfumaryl-CoA	3-Hydroxypropionate bi-cycle	K14449	9	6	12	8	23	5	37	59	73	57	6	0	3	15	48	18	18	27	19	19	41	62	58	3	5	6	13	14	0	8	12	19	19	1	12	27	61	48	1	0	6	0	1	5	2	4	9	37	2	0	10	0	2	32	28	54	65
2-Methylfumaryl-CoA to 3-Methylfumaryl-CoA	3-Hydroxypropionate bi-cycle	K14470	1	0	0	0	0	1	0	1	1	0	0	5	0	0	1	0	0	1	1	0	0	0	0	0	2	0	0	0	0	0	0	0	1	0	0	1	0	1	0	0	2	0	1	0	0	0	1	1	1	0	1	0	1	0	0	1	0
3-Methylfumaryl-CoA to 3S-Citramalyl-CoA	3-Hydroxypropionate bi-cycle	K09709	5	1	8	1	11	2	18	22	35	22	2	1	4	8	21	7	6	8	10	6	18	43	27	1	3	3	7	7	0	2	1	7	8	6	0	17	25	24	2	0	7	2	3	1	0	1	4	16	4	0	4	0	3	9	12	26	30
3S-Citramalyl-CoA to Acetyl-CoA	3-Hydroxypropionate bi-cycle	K08691	9	8	16	8	29	5	38	63	78	59	5	0	5	17	54	19	21	30	21	21	42	69	60	3	5	6	13	14	0	7	10	20	20	0	15	29	65	52	1	0	6	0	2	4	3	3	10	40	3	0	11	0	2	32	28	56	68